Multi-drug and β-lactam resistance in Escherichia coli and food-borne pathogens

Abstract Antimicrobial resistance (AMR) is one of the top ten global public health threats facing humanity by menacing effective use available antimicrobials for treatment an ever-increasing range infections caused bacteria. Its potential recognize transmission to humans contact with commensal and zoonotic resistant bacteria from animal food sources. The aim this study describe multi-drug (MDR) profile in Campylobacter (n = 541), Salmonella 919) Escherichia coli 2777) isolated samples between 2014 2019 Portugal. susceptibility testing results fluoroquinolones/quinolones, macrolides, 3rd generation cephalosporins, polymyxins, carbapenems, penicillins, aminoglycosides, tetracyclines, sulphonamides, trimethoprim chloramphenicol were clustered using k-modes. Clusters described population (broilers, broilers meat, turkeys, pigs, pig meat), AMR classification (mono/dual-resistance, MDR 3-4, 5-6 ≥7), β-lactamases production, sample stage (farm, slaughterhouse, processing plant, retail), season, year. Overall, suggest escalating behavior farm post-farm stages all bacteria, including E. critically important antimicrobials, that (fluoro)quinolones may be associated broilers. Most ESBL/AmpC producing both C3G C4G isolates (respectively, 77%; n 846; 74%; 188). statistical method, K-modes, offers overall visualization data identification profiles have been further surveillance variables. Our provide relevant information support policy decision making tackle stages. Key messages • An multi drug antimicrobials.